Подробное описание документа

Slitikov P. V., Evdokimenkova Yu. B.
   Aminomethylated Hydroxinaphthalenes: Synthesis and Application / Slitikov P. V., Evdokimenkova Yu. B. - URL: https://vestniken.bmstu.ru/catalog/chem/orch/966.html (дата обращения: 11.03.2026). - DOI 10.18698/1812-3368-2021-1-126-143 // Вестник МГТУ им. Н. Э. Баумана. Сер. Естественные науки. - 2021. - № 1. - С. 126-143.

Скачать документ

Полнотекстовый документ

DOI 10.18698/1812-3368-2021-1-126-143

https://doi.org/10.18698/1812-3368-2021-…

vestniken.bmstu.ru/catalog/chem/orch/966.html

https://vestniken.bmstu.ru/catalog/chem/…

The analysis of the literature is carried out and the results of the synthetic approaches to the aminomethylation of hydroxy derivatives of naphthalenes developed over the past 20 years are presented. Most of the described aminomethylation processes proceed as Mannich aminomethylation or, as a special case of a similar condensation — aminobenzylation according to Betti. The results of all studies are grouped according to the nature of the amine used in the synthesis: primary, secondary, tertiary. Most of the examples were considered for 2-naphthol, however, as the analysis of literature data shows, similar methods are applicable to 1-naphthol and dihydroxynaphthalenes with different positions of OH groups in the ring — often only the yields of the target product differ. Both the classical methods for the preparation of Mannich and Betti bases using the carbonyl component (formaldehyde, benzaldehyde and its derivatives, respectively) and special cases of synthesis, in which condensation is carried out by means of halogen derivatives, substituted azacrown ethers, etc., are presented. Particular attention is paid to the use of various catalysts and activators, allowing to significantly simplify the synthetic procedures and increase the yields of target compounds. The main fields of application of aminomethylated derivatives of hydroxynaphthalenes are presented