Подробное описание документа

   Dioxidine Prolonged Release Systems Based on Hydrolyzed Collagen: Cryochemical Synthesis and Properties / Vernaya O. I., Makeeva A. A., Ryzhkova A. S., Semenov A. M., Shabatina T. I. // Наука, технологии и бизнес : материалы 6-ой Межвузовской конференции аспирантов, соискателей и молодых учёных, Москва, 16-18 апреля 2024 года / МГТУ им. Н. Э. Баумана (национальный исследовательский университет). - М., 2024. - С. 82-85.

One of the modern problems of pharmaceutical chemistry is the regulation of health status and local medicine in the patient's hospital. This work examines biocomposites based on hydrolyzed collagen containing the antibacterial drug dioxidine. It has been shown that by changing the synthesis parameters (the concentration of hydrolyzed collagen and the time of formaldehyde cross-linking), it is possible to obtain polymer matrices with different morphology, different time of the antibacterial drug release and the destruction of the matrix. The composition and structure of composite systems based on hydrolyzed collagen containing dioxidine are described using SEM, IR and UV spectroscopy. The antibacterial activity of the dioxidin/hydrolyzed collagen system against E. coli and S. aureus was characterized by the disk diffusion method.
Keywords: cryochemical synthesis, low-temperature synthesis, dioxidine, hydrolyzed collagen, controlled drug release, biopolymer matrices